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Heart Disease: Maintenance and Recovery

Impact on Heart Risk of Attack The CB1 Receptors Heart Rate and

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18.06.2018

Content:

  • Impact on Heart Risk of Attack The CB1 Receptors Heart Rate and
  • Marijuana and Cardiovascular Disease
  • Introduction
  • Can consuming cannabis increase your risk of heart attack? Read all The Impact of CB1 Receptors on Heart Rate and Heart Attack Risk. CB-1 receptors are expressed in the The ECS comprises the cannabinoid receptors (CB-1 and involved in the regulation of heart rate in modulating cardiometabolic risk, effects of cannabis and cannabinoids, with minimal adverse effects. Likely Side Effect Profiles of Drugs Targeting Broadly Expressed Metabotropic and Ionotropic Cannabinoid Receptors channel family, some problems persist. patients at risk for scalding injury. including changes of heart rate as well.

    Impact on Heart Risk of Attack The CB1 Receptors Heart Rate and

    Exogenous Cannabinoids and CVD: Paradoxes and Therapeutic Potential Exogenous cannabinoids refer to cannabinoids that are obtained from the plant Cannabis sativa phytocannabinoids or synthesized analogs.

    Potential therapeutic avenues are explored below: Modulation of CB1 Recent studies suggest that CB1 receptors play a major role in cardiovascular regulation. Modulation of CB2 There is experimental evidence implying CB2 receptors are involved in the progression of atherosclerosis. Modulation of Ionotropic Cannabinoid Receptors Vanilloid receptors mediate the response of cardiac spinal afferent nerves after an ischemic period and act as molecular sensors to detect myocardial and tissue ischemia and activating cardiac nociceptors.

    Notes J Am Heart Assoc. Heart disease and stroke statistics— update: Pacher P, Steffens S. The emerging role of the endocannabinoid system in cardiovascular disease.

    What has research over the past two decades revealed about the adverse health effects of recreational cannabis use? Cumulative lifetime marijuana use and incident cardiovascular disease in middle age: Am J Public Health. Lifetime marijuana use and subclinical atherosclerosis: National Academies of Sciences E, and Medicine.

    The health effects of cannabis and cannabinoids: The current state of evidence and recommendations for research. The National Academies Press; Lipids, lipoproteins, atherosclerosis and cardiovascular disease. Cannabinoid receptors in acute and chronic complications of atherosclerosis. Myocardial ischemia and reperfusion injury. Prevention of cardiovascular diseases: A review of the cost of cardiovascular disease. Mice lacking functional TRPV1 are protected from pressure overload cardiac hypertrophy.

    The role of autophagy in cardiac hypertrophy. Acta Biochim Biophys Sin. Matsuzawa Y, Lerman A. Endothelial dysfunction and coronary artery disease: Impact of oxidative stress on the heart and vasculature: J Am Coll Cardiol. Burton GJ, Jauniaux E. Oxidative stress and cardiovascular risk: Exercise and its role in the prevention and rehabilitation of cardiovascular disease.

    Am J Cardiovasc Drugs. Istvan ES, Deisenhofer J. Effect of statins on skeletal muscle: Exerc Sport Sci Rev. Indian J Endocrinol Metab. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med. Endocannabinoid system in cardiovascular disorders—new pharmacotherapeutic opportunities. J Pharm Bioallied Sci. Zhong B, Wang DH. TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice.

    Harv Mens Health Watch. Mechoulam R, Parker LA. The endocannabinoid system and the brain. Effects of neuroendocrine CB1 activity on adult leydig cells. Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase. Cardiovascular actions of cannabinoids and their generation during shock.

    J Mol Med Berl. Multiple pathways involved in the biosynthesis of anandamide. CB1 cannabinoid receptor inhibition: The endocannabinoid system as an emerging target of pharmacotherapy. Biochem Biophys Res Commun. Guindon J, Hohmann AG. The endocannabinoid system and pain. Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages.

    Kannampalli P, Sengupta JN. Role of principal ionotropic and metabotropic receptors in visceral pain. Molecular aspects of cannabinoid receptors. Cannabinoid CB 2 receptors in health and disease. Dhopeshwarkar A, Mackie K. CB 1 cannabinoid receptors and their associated proteins.

    Basu S, Dittel BN. Unraveling the complexities of cannabinoid receptor 2 CB2 immune regulation in health and disease. Transient receptor potential channels: Nat Rev Drug Discov.

    Kaneko Y, Szallasi A. Transient receptor potential TRP channels: Why do cannabinoid receptors have more than one endogenous ligand? Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels.

    Endocannabinoids as regulators of transient receptor potential TRP channels: Cannabinoid actions at TRPV channels: Opportunistic activation of TRP receptors by endogenous lipids: Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents.

    Vascular targets for cannabinoids: Cardiovascular consequences of marijuana use. Mini Rev Med Chem. Kogan NM, Mechoulam R.

    Cannabinoids in health and disease. Cannabinoids and atherosclerotic coronary heart disease. Steffens S, Pacher P. Targeting cannabinoid receptor CB 2 in cardiovascular disorders: Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity.

    Substance P distribution and effects in the canine epicardial coronary arteries. CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages. Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages.

    Cannabinoid CB1 receptor inhibition decreases vascular smooth muscle migration and proliferation. Arterioscler Thromb Vasc Biol. Emerging role of the cannabinoid receptor CB2 in immune regulation: Expert Rev Mol Med. Triggering myocardial infarction by marijuana. An exploratory prospective study of marijuana use and mortality following acute myocardial infarction. Chami AT, Kim C. Cannabis abuse and risk for myocardial infarction: Apart from the effects that active-ingredient marijuana has on the body, the delivery method for the drug raises other concerns.

    Substances within the inhaled smoke, such as carbon monoxide and burnt plant particles, can harm lung tissues and damage small blood vessels. This is like tobacco smoking, which can have negative effects on the heart and can also lead to strokes, especially in patients with existing heart and circulatory problems. There are no definitive, rigorous scientific studies to guide us about marijuana use because the drug was illegal for many decades. All the observational studies have limited credibility due to other confounding factors such as genetic manipulation of marijuana types and strains, quantification of the use, adverse health behaviors—such as increased calorie intake, obesity, tobacco, alcohol, and cocaine use, and association with HIV.

    The study by Kalla et al, 6 has similar limitations. Even adjusting for these factors, the actual cardiovascular risk may be over- or underestimated. Long-term studies have failed to show a definite increase in cardiovascular mortality with marijuana use. Drug Enforcement Administration, Department of Justice. Establishment of a new drug code for marihuana extract.

    Accessed July 17, Effect of cannabis smoking on lung function and respiratory symptoms: Cochrane Database Syst Rev. Cannabinoids for medical use: Hall W, Degenhardt L. Cannabis use and the risk of developing a psychotic disorder. Cannabis use predicts risks of heart failure and cerebrovascular accidents: J Am Coll Cardiol. Cumulative lifetime marijuana use and incident cardiovascular disease in middle age: Am J Public Health. Marijuana use and mortality. Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease: Effect of rimonabant on carotid intima-media thickness CIMT progression in patients with abdominal obesity and metabolic syndrome: Kattoor A, Mehta JL.

    Marijuana and coronary heart disease.

    Marijuana and Cardiovascular Disease

    Research suggests that the risk of heart attack is several times may increase the long-term death rate among heart attack survivors. So it's hard to separate the effects of cannabinoid compounds on These are the active ingredients that bind to specific receptors in the brain and other parts of the body. in cardiovascular disease; activation of cannabinoid receptor 2 (CB2R) exerts .. increased risk of developing cardio vascular disease In this context, clinical .. effects on heart rate and blood pressure, both in experi‑. smoking on heart rate and blood pressure, the cardiovas- cular effects of D9- tetrahydrocannabinol (THC, the main psychotropic ingredient in cardiac injury protection, metabolic cardiovascular risk factors and (GPCRs), known as cannabinoid receptors of type 1 (CB1) and 2 (CB2) .. development of heart failure. In this.

    Introduction



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    Panache

    Research suggests that the risk of heart attack is several times may increase the long-term death rate among heart attack survivors. So it's hard to separate the effects of cannabinoid compounds on These are the active ingredients that bind to specific receptors in the brain and other parts of the body.

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