CBD and THC get a lot of the fame, but there are actually a bunch of cannabinoids In addition, two compounds called tetrahydrocannabinolic acid ( THCA) Other cannabinoids include cannabigerol (CBG), cannabichromene ( CBC), and The difference between CBD oil and hemp oil (not to be confused with hemp seed. THC, CBD, CBN, CBC, CBG and about 80 other chemicals are all in a class of DeltaTetrahydrocannabinol or (THC) is a psychoactive. THC, CBD, CBN, CBC, and CBG are all cannabinoids. THC or Delta Tetrahydrocannabinol is the psychoactive cannabinoid found in the cannabis plant.
how and it gets confusing CBD, THCA,CBG THC,
Because patients use cannabis for different conditions and respond to it uniquely, there is no standard dose that guarantees effective treatment or a manageable level of intoxication for all. There are several phytocannabinoids in each strain of cannabis plants, all containing varying amounts depending on plant genetics and growing conditions.
Terpenes, the chemicals in cannabis that are responsible for aroma, are also active compounds that have significant medical value. The interaction of all these components in the cannabis plant is more effective than any component taken alone. To mitigate the occurrence and strength of undesired side effects, patients are encouraged to start with a very low dose, slowly increase the dose, and stop increasing intake when effective relief or undesired effects occur.
This is especially true for patients who are inexperienced using cannabis, though it is also true for experienced patients trying a new product or formulation. Self-titration of cannabis dosing is safe, considering the low toxicity of cannabis. This recommendation is not unique to cannabis, as there are other drugs with low toxicity and high dosing limits, gabapentin being a well-known example, titrated to best effects with tolerable side effects.
Patients are also familiar with titrating non-prescription medicines like aspirin, acetaminophen, and caffeine. Still, we try to define a standard dose of medicinal cannabis.
How do we accommodate individual differences, minimize adverse effects and maximize therapeutic benefits? In addition, the effect of cannabinoids taken in combination is often different than the effects of the same dose of cannabinoids in isolation. Strain names are not only of little use in medical cannabis, but may be cause for concern. This can be due to erroneous labeling, to shifting plant constituents from one crop to the next, or even time of harvest. Because patients cannot depend on strain names for consistent therapeutic effects they must rely on accurate lab testing for cannabinoids and terpenes.
With more reliable lab analysis product testing and quality assurance and ongoing patient data and feedback, we can provide better guidance regarding effective cannabis chemotypes for specific needs. Although medical cannabis research has been growing and accelerating in recent years, there remains a gap between the medical cannabis tested in clinical studies and the cannabis that patients are actually using. Many factors affect outcome.
Lab analysis is not yet as reliable as we would expect. The equipment for full and accurate testing is expensive and not all labs have adequate facilities. Tiny samples from different parts of the plant, the method of sample preparation, mathematical errors, and calibrated testing equipment all affect the final results.
The same medicine can be submitted to several different labs and different analyses will result. Which can be trusted? Clinical trials use synthetic or purified phytocannabinoid compounds, derivatives from undescribed cannabis strains, or plant material with incomplete chemotype descriptions.
Both anecdotal and referenced evidence describes purified phytocannabinoid medication as less effective than botanical extracts. How do we begin to reconcile these seemingly disparate results?
Or are they disparate? Should we acknowledge we are working with a botanical with many active compounds synergizing positively and perhaps, at times, negatively? While the studies are providing valuable information about the validity of cannabis as medicine, many of them may not be providing information that directly applies to patients.
To further complicate matters, much of the anecdotal evidence come from patients who do get their medicine at dispensaries, where there are natural variations in batches and strains as well as unreliable availability.
This puts the responsibility on dispensaries to provide patients with consistent medicine backed by accurate lab analyses. Responsibility then shifts to the patient to provide accurate feedback to the dispensary on varieties, amounts, and methods of administration for each medical problem being treated.
All federally approved studies done in the U. These joints can range from mg of THC, but patients are often not required to smoke the entire joint. These drugs are pharmaceuticals and are not available at medical cannabis dispensaries.
Patients who get their medicine at dispensaries are using whole plant medicine—extracts that are made from the whole cannabis plant and that therefore have a more complex cannabinoid profile. Patients are being discouraged from smoking, however for those patients who choose to smoke there are many more options including vaporizing, pipes, joints, and dabs smoking extracts for which there is little research on actual cannabinoid delivery.
CBD doses are best documented in treating epilepsy, with doses ranging from 2 to 11 mg CBD per pound of body weight. Dosing is directly related to delivery method, to chemotype and concentration, and to potency.
For example, the potency of one gram of a concentrate differs drastically from the potency of one gram of dried flower. Smoking has been the most common form of delivery for many years. Absorption through the lungs is effective and rapid. Cannabis is going mainstream. People are curious about the compounds called cannabinoids found in this plant—which has been used for its medicinal purposes for centuries—and how they might benefit their health , especially when it comes to reducing the use of prescription drugs and over-the-counter medications.
Despite its growing fame and recognition, there's still a lot of misinformation about cannabis, hemp, CBD oil, and the industry in general, which doesn't help its progress. As the health editor at mindbodygreen and the author of the forthcoming book CBD Oil: Everyday Secrets , I know firsthand how important it is to get the facts straight so that more people can start getting access to and benefiting from cannabis. To begin, it's important to know that when we talk about CBD, hemp oil, marijuana, and THC, we're really talking about the cannabis plant and its derivates.
Because while there are important legal differences between hemp and marijuana, when it comes to the science, hemp and marijuana are actually just two versions of the cannabis plant.
This causes a lot of confusion and it is, admittedly, confusing! Cannabinoid is a name that describes a ground of similar compounds that are found in the body called endocannabinoids , found naturally in plants called phytocannabinoids , and even made in a lab in this case they're called synthetic cannabinoids.
Cannabinoids interact with a larger system in the body called the endocannabinoid system ECS , which is often described as a major regulatory system. The ECS is responsible for the side effects good and bad of using cannabis—whether that be in the form of hemp oil, CBD oil, or smoking marijuana.
The endocannabinoid system is composed of the endocannabinoids that the body produces naturally and also a family of receptors called cannabinoid receptors. The two cannabinoid receptors to know about are CB1 and CB2, and they explain in large part why cannabis has so many healing properties and also why THC causes intoxication while CBD does not.
Speaking of CBD and THC, it's important to know the difference between these two distinct compounds that interact with the body in very different ways.
THC directly binds to CB1 receptors in the body, which are mainly found in the brain and nervous system. Once you know this, it's no big surprise to learn that this CB1 receptor activation is responsible for the "high" from smoking cannabis and that CBD does not directly bind with that receptor. Instead, CBD interacts with other receptors and pathways in the body that explain many of its specific health benefits.
CBD and THC have been described as "sister molecules" and one of the most interesting aspects of cannabinoid science is the " entourage effect, " which says that cannabinoids are more effective together than they are alone in isolated preparations. This is part of the reason why when you're looking for cannabis products, experts recommend full-spectrum products which include some of the other cannabinoids and terpenes of the plant and to steer clear of isolates, which only contain the single compound and are generally less effective and more difficult to dose.
CBD and THC get a lot of the fame, but there are actually a bunch of cannabinoids worth learning about. Cannabinol CBN , which was actually the first cannabinoid to be discovered, is often used specifically for sleep.
Other cannabinoids include cannabigerol CBG , cannabichromene CBC , and tetrahydrocannabivarin THCV , which are all of interest to doctors and researchers for their specific health benefits. Unfortunately, many of these cannabinoids have barely been studied. Cannabinoids have a wide range of health benefits, ranging from THC's pain-relieving qualities to CBD's anti-anxiety properties.
Other areas of research include cannabinoid therapy for PTSD, seizures, depression and anxiety , cancer and cancer-treatment-related symptoms , pain, and addiction especially to opioids. Most of these areas of research are in the preliminary stages, although a CBD-derived pharmaceutical drug was just approved by the FDA for seizure disorders, and THC-based drugs have been available for pain and a few other conditions for quite some time.
As research continues, we'll better understand cannabis and the health benefits of specific cannabinoids. Unfortunately, though, the way current laws are set up, it's extremely difficult to get approval to study cannabis and even more difficult and time-intensive to get high-quality plant materials to use in research.
Hopefully, as more patients ask their doctors about cannabis-based therapies and more states approve recreational and medicinal marijuana, that will change. The difference between CBD oil and hemp oil not to be confused with hemp seed oil, which is made from the sterilized seeds of the plant and doesn't have significant cannabinoid content can also be a source of confusion.
Since CBD, in contrast to THC, is not a controlled substance in the . CBG, THCA , CBGA and others, depending from cannabis strain and misconceptions that may confuse the final users of this preparations still exist. Here we list the major ones, such as THC and CBD, and some of their potential effects. What Is THCA & What Are the Benefits of This Cannabinoid?. High-grade glioma is one of the most aggressive cancers in adult humans and . were % CBD, % THC, % CBG, % CBC, % % THCA, % CBN, and % CBO. .. It is unclear whether or not cannabinoid activity is.