Cannabidiol, or CBD, is a chemical compound in marijuana with a variety of uses . Tetrahydrocannabinol (THC) is the main psychoactive cannabinoid found mental health disorders that can have devastating impacts on health and of CBD and THC in people with cancer-related pain who did not. Nonetheless, some side effects have been reported for CBD, but mainly in vitro . CBD inhibition of the BCRP efflux function in the placental cotyledon b.w. i.p. ) did not affect blood pressure, heart rate, body temperature, Peres et al., list five animal studies, where mostly 30 mg/kg CBD was administered. THC and CBD are the two most abundant naturally occurring cannabinoids with It also has medicinal uses for a multitude of symptoms including; mild to . Some of us refer to that as 'creeper' bud when the effect doesn't seem to Cannabinoids only affect us because our bodies contain these receptors.
of just does effects, has the functions body. CBD not affect major side and few a the mild
A press release by GW Pharmaceuticals of September 15th, , described 88 patients with treatment-resistant schizophrenic psychosis, treated either with CBD in addition to their regular medication or placebo. Important clinical parameters improved in the CBD group and the number of mild side effects was comparable to the placebo group. Moreover, neurological and physiological examinations were performed, which neither showed signs of CBD toxicity nor severe side effects.
The study also illustrated that CBD was well tolerated. CBD in addition to their regular epilepsy medication. Another clinical study lasting at least 3 months with children and young adults with various forms of epilepsy, who were treated with the CBD drug Epidiolex, was presented at the American Academy for Neurology in In a few cases, severe side effects occurred, but it is not clear, if these were caused by Epidiolex.
The largest CBD study conducted thus far was an open-label study with Epidiolex in patients mainly children, the average age of the participants was 11 suffering from severe epilepsy, who could not be treated sufficiently with standard medication. Ten percent of the patients reported side effects tiredness, diarrhea, and exhaustion. After extensive literature study of the available trials performed until September , CBD side effects were generally mild and infrequent. The only exception seems to be a multicenter open-label study with a total of patients aged 1—30 years, with treatment-resistant epilepsy.
This led to a reduction in seizure frequency. It is therefore difficult to put the side effect frequency into perspective. Attributing the side effects to CBD is also not straightforward in severely sick patients. Thus, it is not possible to draw reliable conclusions on the causation of the observed side effects in this study. This rating instrument comprised the following factors: This assessment instrument analyzes adverse medication effects, including psychic, neurologic, autonomic, and other manifestations.
Using various safety outcome variables, clinical tests, and the cannabis side effect inventory, it was shown that there were no differences between the placebo group and the CBD group in the observed side effects. The occurrence of various degrees of GVHD was compared with historical data from patients, who had only received the standard treatment. This resulted in lower resistin levels compared to baseline. The hormone resistin is associated with obesity and insulin resistance.
Compared to baseline, glucose-dependent insulinotropic peptide levels were elevated after CBD treatment. This incretin hormone is produced in the proximal duodenum by K cells and has insulinotropic and pancreatic b cell preserving effects.
CBD was well tolerated in the patients. However, with the comparatively low CBD concentrations used in this phasetrial, no overall improvement of glycemic control was observed. When weight and appetite were measured as part of a measurement battery for side effects, results were inconclusive. For instance, the study mentioned above, where 23 children with Dravet syndrome were treated, increases as well as decreases in appetite and weight were observed as side effects. However, in the safety analysis group, consisting of subjects, 10 showed decreased weight and 12 had gained weight.
Both these factors were not controlled for in the reviewed studies. This review could substantiate and expand the findings of Bergamaschi et al. First, more studies researching CBD side effects after real chronic administration need to be conducted. Many so-called chronic administration studies, cited here were only a couple of weeks long. Second, many trials were conducted with a small number of individuals only. To perform a throrough general safety evaluation, more individuals have to be recruited into future clinical trials.
Third, several aspects of a toxicological evaluation of a compound such as genotoxicity studies and research evaluating CBD effect on hormones are still scarce. Especially, chronic studies on CBD effect on, for example, genotoxicity and the immune system are still missing.
Last, studies that evaluate whether CBD-drug interactions occur in clinical trials have to be performed. In conclusion, CBD safety profile is already established in a plethora of ways. However, some knowledge gaps detailed above should be closed by additional clinical trials to have a completely well-tested pharmaceutical compound. The study was commissioned by the European Industrial Hemp Association.
EIHA paid nova-Institute for the review. Iffland K, Grotenhermen F An update on safety and side effects of cannabidiol: National Center for Biotechnology Information , U. Journal List Cannabis Cannabinoid Res v.
Published online Jun 1. Find articles by Kerstin Iffland. Find articles by Franjo Grotenhermen. Author information Copyright and License information Disclaimer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article has been cited by other articles in PMC. Relevant Preclinical Studies Before we discuss relevant animal research on CBD possible effects on various parameters, several important differences between route of administration and pharmacokinetics between human and animal studies have to be mentioned. Open in a separate window. The reality is more complex, because CBD is lipophilic and, for example, will consequently accumulate in fat tissue.
These calculations were made with the intention to give the reader an impression and an approximation of the supraphysiological levels used in in vitro studies. CBD-drug interactions Cytochrome Pcomplex enzymes This paragraph describes CBD interaction with general drug -metabolizing enzymes, such as those belonging to the cytochrome P family.
Neurological and neurospychiatric effects Anxiety and depression Some studies indicate that under certain circumstances, CBD acute anxiolytic effects in rats were reversed after repeated day administration of CBD.
Psychosis and bipolar disorder Various studies on CBD and psychosis have been conducted. Addiction CBD, which is nonhedonic, can reduce heroin-seeking behavior after, for example, cue-induced reinstatement. Neuroprotection and neurogenesis There are various mechanisms underlying neuroprotection, for example, energy metabolism whose alteration has been implied in several psychiatric disorders and proper mitochondrial functioning.
Immune system Numerous studies show the CBD immunomodulatory role in various diseases such as multiple sclerosis, arthritis, and diabetes. Cell migration Embryogenesis CBD was shown to be able to influence migratory behavior in cancer, which is also an important aspect of embryogenesis.
Cancer Various studies have been performed to study CBD anticancer effects. Food intake and glycemic effects Animal studies summarized by Bergamaschi et al. Genotoxicity and mutagenicity Jones et al. Acute Clinical Data Bergamaschi et al.
Physiological effects In a double-blind, placebo-controlled crossover study, CBD was coadministered with intravenous fentanyl to a total of 17 subjects. Psychosis The review by Bergamaschi et al. Addiction A case study describes a patient treated for cannabis withdrawal according to the following CBD regimen: Endocrine effects and glycemic including appetite effects To the best of our knowledge, no acute studies were performed that solely concentrated on CBD glycemic effects.
Physiological effects A first pilot study in healthy volunteers in by Mincis et al. Neurological and neuropsychiatric effects Anxiety Clinical chronic lasting longer than a couple of weeks studies in humans are crucial here but were mostly still lacking at the time of writing this review.
Psychosis and bipolar disorder In a 4-week open trial, CBD was tested on Parkinson's patients with psychotic symptoms. Conclusion This review could substantiate and expand the findings of Bergamaschi et al. Safety and side effects of cannabidiol, a Cannabis sativa constituent. Cannabis und Cannabinoide in der Medizin: Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. Controlled clinical trial of cannabidiol in Huntington's disease.
Molecular targets of cannabidiol in neurological disorders. Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: Distinct effects of D9-tetrahydro-cannabinoland cannabidiol on neural activation during emotional processing. Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans. Inhibition and induction of human cytochrome P CYP enzymes.
How physicochemical properties of drugs affect their metabolism and clearance. New horizons in predictive drug metabolism and pharmacokinetics. Royal Society of Chemistry: Human metabolites of cannabidiol: Induction and genetic regulation of mouse hepatic cytochrome P by cannabidiol.
ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice.
Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: Am J Obstet Gynecol.
Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice. Cannabidiol, among other cannabinoid drugs, modulates prepulse inhibition of startle in the SHR animal model: Cannabidiol attenuates sensorimotor gating disruption and molecular changes induced by chronic antagonism of NMDA receptors in mice.
Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania. Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances. Schurr A, Livne A. Differential inhibition of mitochondrial monoamine oxidase from brain by hashish components.
Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxicischemic newborn piglets. Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain. Inhibiting heat shock proteins can potentiate the cytotoxic effect of cannabidiol in human glioma cells. Cannabidiol CBD and its analogs: The antitumor activity of plant-derived non-psychoactive cannabinoids. Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer's disease transgenic mice.
Cannabidiol arrests onset of autoimmune diabetes in NOD mice. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. Id-1 gene and protein as novel therapeutic targets for metastatic cancer. The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. Pharmacological targeting of ion channels for cancer therapy: Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule Gene and protein as novel therapeutic targets for metastatic cancer.
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. Delta9-tetrahydrocannabinol and cannabidiol as potential curative agents for cancer: Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. Efficacy and safety of cannabidiol and tetrahydrocannabivarin on glycemic and lipid parameters in patients with type 2 diabetes: Marijuana extracts possess the effects like the endocrine disrupting chemicals.
Inhibition of hepatic microsomal cytochrome P by cannabidiol in adult male rats. Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. As one of the original CBD manufacturers, Green Roads reputation truly precedes them, and their pharmacist formulated manufacturing process is why we selected them as the best quality CBD oil on the market.
They offer a range of CBD oil concentrations mg, mg, mg, mg, mg, mg, and 3,mg all of which allow you to view ingredients and test results from a 3rd party testing facility via a QR code on the box. Though unflavored and priced higher than competitors, Green Roads CBD oils are made by a trusted manufacturer and use organically grown hemp.
Tinctures are available in 30mL containers and mg, mg, mg, 2,mg, and 4,mg concentrations. These products come in watermelon or peppermint flavors. These products do not contain any THC and pose no risk for drug test takers. As a general rule of thumb, low-concentration oils are a good option for smaller dogs while larger concentrations may be more suitable for larger breeds — but pet owners should always check with their vet beforehand.
Cannabidiol, or CBD for short, is a natural phyto-cannabinoid or plant-based chemical compound found in cannabis plants, including hemp and marijuana. Unlike other cannabinoids — namely tetrahydrocannabinol, or THC — CBD does not produce any psychoactive effects, and will actually counteract these effects to a degree.
CBD can enter the body in many ways, including as an oil extract. This guide will discuss how CBD oils help induce sleep in users, explore safety and legal concerns associated with these products, share some tips for first-time buyers, and list our picks for the top CBD oils for sleep that are sold today.
CBD oil derived from marijuana is subject to stricter state and federal laws than oil derived from hemp. As a result, the former is more difficult to legally obtain in certain parts of the U.
For this reason, our recommendations in this guide will exclusively focus on hemp-based CBD oils. While we at Tuck. Before trying CBD oil for the first time, please consult your doctor to ensure this product is right for you. CBD is naturally occurring, and is among the largest cannabinoids found in hemp and marijuana.
The human body also produces cannabinoids, known as endocannabinoids, in a bodily system known as the endocannabinoid system or ECS. The ECS promotes homeostasis by regulating a wide range of functions, including motor skills, mood, appetite, and sleep. As we age, our ECS produces fewer endocannabinoids; they may also decrease due to physical injury or disease. Replenishing depleted endocannabinoids with phytocannabinoids like CBD can help restore balance to the body.
As a rule, CBD oil extracted from hemp will contain no more than 0. CBD oils extracted from hemp generally fall into one of the following three categories: The vast majority of CBD oils come in bottles measuring either 15 milliliters mL , or 0. However, CBD concentration is more important than bottle size. Concentration refers to the ratio of hemp oil solution measured in mL compared to the amount of CBD cannabinoid measured in milligrams, or mg.
A mL bottle may contain mg of CBD, mg, mg, or more. The higher the mg amount, the stronger the CBD oil will be. How much CBD oil you should take largely depends on your bodyweight, as well as the desired effects. The next table breaks down the effects of different doses based on these two factors.
Always consult your physician to determine the best dosage for you. CBD oil alleviates physical pain and anxiety — both of which can have a negative impact on sleep. Additionally, CBD oil can actually prolong sleep for some, leading to more rest from night to night. However, please note that the medicinal effects of CBD oil have not been studied extensively. While many medical patients claim the oils improve sleep quality and duration, more clinical trials are needed to determine how and why these improvements occur — and if they are applicable to all individuals.
Additionally, CBD oil is also associated with some negative side effects. CBD oil is considered therapeutic and low-risk for most users. However, CBD oil may result in the following adverse effects: This may be the desired effect.
In recent years, the legality of CBD oil and other products derived from hemp or marijuana has been a hot-button issue. Historically, hemp could legally be grown and cultivated for academic research purposes only. However, the legality of hemp growth has changed in the past year. In April , Sen. Mitch McConnell of Kentucky introduced the Hemp Farming Act of , a piece of legislation that proposed legalizing all hemp products at the federal level.
Per the farm bill, industrial hemp will be descheduled as a federally controlled substance. Still, the legality of marijuana-based CBD oil also varies from state to state.
The table below lists general guidelines for hemp- and marijuana-based CBD oil consumption based on different state laws. These states have more complex laws pertaining to hemp- and marijuana-based CBD oils. These initiatives may have a bearing on the legality and availability of CBD oils.
Three other states, Arizona, Missouri, and Nebraska, failed to garner enough votes to place marijuana initiatives on the ballots. These laws are ever-changing, and the guidelines listed above should not substitute for legal advice.
When purchasing hemp-derived CBD oil for sleep, you may be able to find products through one or more of the following establishments: Cost is another consideration. Most CBD oils are sold in concentrations of to mg, although this may range from less than mg to more than 2, A good indicator of price-point is the cost per milligram. Low-cost CBD oils usually fall between five and 10 cents per mg; mid-range prices are 11 to 15 cents per mg; and higher-end oils cost 16 cents per mg or higher.
Although price may be an indicator of CBD oil quality, we suggest researching the following factors to ensure the oil you select is considered high-quality. Some forms of CBD oil — such as vapors and tinctures — normally have higher-than-average concentrations, whereas sprays and topicals tend to have lower concentrations.
When buying CBD oil for the first time and comparing different products, here are a few variables to keep in mind: As noted in the previous section, CBD oil prices vary significantly by brand.
The best practice for most is to determine a per-milligram budget for CBD oil, as well as a maximum price for the entire bottle. In the United States research about medical cannabis has been hindered by federal law. The most prevalent psychoactive substances in cannabis are cannabinoids , particularly THC.
There are similar compounds in cannabis that do not exhibit psychoactive response but are obligatory for functionality: How these other compounds interact with THC is not fully understood.
Some clinical studies have proposed that CBD acts as a balancing agent to regulate the strength of the psychoactive agent THC. CBD is believed to regulate the metabolism of THC by inactivating cytochrome P , an important class of enzymes that metabolize drugs. The essential oil of cannabis contains many fragrant terpenoids which may synergize with the cannabinoids to produce their unique effects. THC and cannabidiol are neuroprotective antioxidants.
Research on rats has demonstrated that THC prevents hydroperoxide -induced oxidative damage as well as or better than other antioxidants in a chemical Fenton reaction system and neuronal cultures.
Cannabidiol was significantly more protective than either vitamin E or vitamin C. The cannabinoid receptor is a typical G protein-coupled receptor. A characteristic of this type of receptor is the distinct pattern of how the molecule spans the cell membrane seven times.
Cannabinoid receptors are located on the cell membrane, and both outside extracellularly and inside intracellularly the cell membrane. CB1 receptors, the bigger of the two, are extraordinarily abundant in the brain: CB2 receptors are most prevalent on B-cells , natural killer cells , and monocytes , but can also be found on polymorphonuclear neutrophil cells , T8 cells , and T4 cells.
In the tonsils the CB2 receptors appear to be restricted to B-lymphocyte -enriched areas. THC and its endogenous equivalent anandamide additionally interact with glycine receptors. Cannabinoids usually contain a 1,1'-di-methyl-pyran ring, a variedly derivatized aromatic ring and a variedly unsaturated cyclohexyl ring and their immediate chemical precursors, constituting a family of about 60 bi-cyclic and tri-cyclic compounds.
Like most other neurological processes, the effects of cannabis on the brain follow the standard protocol of signal transduction , the electrochemical system of sending signals through neurons for a biological response.
It is now understood that cannabinoid receptors appear in similar forms in most vertebrates and invertebrates and have a long evolutionary history of million years. There are at least two types of cannabinoid receptors CB1 and CB2. The CB2 receptor is most abundantly found on cells of the immune system. Cannabinoids act as immunomodulators at CB2 receptors, meaning they increase some immune responses and decrease others. For example, nonpsychotropic cannabinoids can be used as a very effective anti-inflammatory.
It is clear that cannabinoids can affect pain transmission and, specifically, that cannabinoids interact with the brain's endogenous opioid system and may affect dopamine transmission. Most cannabinoids are lipophilic fat soluble compounds that are easily stored in fat, thus yielding a long elimination half-life relative to other recreational drugs. The THC molecule, and related compounds, are usually detectable in drug tests from 3 days up to 10 days according to Redwood Laboratories; long-term users can produce positive tests for two to three months after ceasing cannabis use see drug test.
No fatal overdoses with cannabis use have been reported. THC , the principal psychoactive constituent of the cannabis plant, has an extremely low toxicity and the amount that can enter the body through the consumption of cannabis plants poses no threat of death. It is important though to note that cannabinoids and other molecules present in cannabis can alter the metabolism of other drugs, especially due to competition for clearing metabolic pathways such as cytochromes CYP ,  thus leading to drug toxicities by medications that the person consuming cannabis may be taking.
A study found that while tobacco and cannabis smoke are quite similar, cannabis smoke contained higher amounts of ammonia , hydrogen cyanide , and nitrogen oxides , but lower levels of carcinogenic polycyclic aromatic hydrocarbons PAHs. Cannabis smoke contains thousands of organic and inorganic chemical compounds. This tar is chemically similar to that found in tobacco smoke or cigars. Other observations include possible increased risk from each cigarette; lack of research on the effect of cannabis smoke alone; low rate of addiction compared to tobacco; and episodic nature of cannabis use compared to steady frequent smoking of tobacco.
Further, he notes that other studies have failed to connect cannabis with lung cancer, and accuses the BLF of "scaremongering over cannabis".
When smoked, the short-term effects of cannabis manifest within seconds and are fully apparent within a few minutes,  typically lasting for 1—3 hours, varying by the person and the strain of cannabis. The psychoactive effects of cannabis, known as a " high ", are subjective and vary among persons and the method of use. When THC enters the blood stream and reaches the brain, it binds to cannabinoid receptors. The endogenous ligand of these receptors is anandamide , the effects of which THC emulates.
This agonism of the cannabinoid receptors results in changes in the levels of various neurotransmitters, especially dopamine and norepinephrine ; neurotransmitters which are closely associated with the acute effects of cannabis ingestion, such as euphoria and anxiety. Abstract or philosophical thinking, disruption of linear memory and paranoia or anxiety are also typical.
Anxiety is the most commonly reported side effect of smoking marijuana. Cannabidiol CBD , another cannabinoid found in cannabis in varying amounts, has been shown to ameliorate the adverse effects of THC, including anxiety, that some consumers experience.
Cannabis produces many other subjective and highly tangible effects, such as increased enjoyment of food taste and aroma, and marked distortions in the perception of time and space where experiencing a "rush" of ideas from long-term memory can create the subjective impression of long elapsed time, while in reality only a short time has passed. In some cases, cannabis can lead to dissociative states such as depersonalization   and derealization.
Any episode of acute psychosis that accompanies cannabis use usually abates after 6 hours, but in rare instances, heavy users may find the symptoms continuing for many days. While psychoactive drugs are typically categorized as stimulant , depressant , or hallucinogen , cannabis exhibits a mix of all of them, perhaps leaning more towards hallucinogenic or psychedelic properties, though with other effects quite pronounced.
THC is considered the primary active component of the cannabis plant. Scientific studies have suggested that other cannabinoids like CBD may also play a significant role in its psychoactive effects. Electroencephalography or EEG shows somewhat more persistent alpha waves of slightly lower frequency than usual.
Peak levels of cannabis-associated intoxication occur approximately 30 minutes after smoking it and last for several hours.
The total short-term duration of cannabis use when smoked depends on the potency, method of smoking — e. Peak levels of intoxication typically last an average of three to four hours.
When taken orally in the form of capsules, food or drink , the psychoactive effects take longer to manifest and generally last longer, typically lasting for an average of four to ten hours after consumption.
Also, oral ingestion use eliminates the need to inhale toxic combustion products created by smoking and therefore negates the risk of respiratory harm associated with cannabis smoking. The areas of the brain where cannabinoid receptors are most prevalent are consistent with the behavioral effects produced by cannabinoids. Brain regions in which cannabinoid receptors are very abundant are the basal ganglia , associated with movement control; the cerebellum , associated with body movement coordination; the hippocampus , associated with learning , memory, and stress control; the cerebral cortex , associated with higher cognitive functions; and the nucleus accumbens , regarded as the reward center of the brain.
Other regions where cannabinoid receptors are moderately concentrated are the hypothalamus , which regulates homeostatic functions; the amygdala , associated with emotional responses and fears ; the spinal cord , associated with peripheral sensations like pain; the brain stem , associated with sleep , arousal , and motor control; and the nucleus of the solitary tract , associated with visceral sensations like nausea and vomiting.
Experiments on animal and human tissue have demonstrated a disruption of short-term memory formation,  which is consistent with the abundance of C receptors on the hippocampus, the region of the brain most closely associated with memory. Cannabinoids inhibit the release of several neurotransmitters in the hippocampus such as acetylcholine , norepinephrine , and glutamate , resulting in a decrease in neuronal activity in that area. Compared to currently approved drugs prescribed for the treatment of Alzheimer's disease, THC is a considerably superior inhibitor of A aggregation, and this study provides a previously unrecognized molecular mechanism through which cannabinoid molecules may impact the progression of this debilitating disease.
While several studies have shown increased risk associated with cannabis use by drivers, other studies have not found increased risk. In Cannabis and driving: Where they can compensate, they do A meta-analysis found that acute cannabis use increased the risk of an automobile crash.
In the largest and most precisely controlled study of its kind carried out by the U. Likewise better controlled studies have found lower or no elevated crash risk estimates". Short-term one to two hours effects on the cardiovascular system can include increased heart rate, dilation of blood vessels, and fluctuations in blood pressure. Indeed, marijuana may be a much more common cause of myocardial infarction than is generally recognized.
In day-to-day practice, a history of marijuana use is often not sought by many practitioners, and even when sought, the patient's response is not always truthful".
A analysis of 3, myocardial infarction survivors over an year period showed "no statistically significant association between marijuana use and mortality".
Effects of cannabis
while others require a heavier dose in order to get the full benefits. CBD has just a few mild side effects and does not affect the major functions of the body. Cannabidiol (CBD) is an active ingredient in cannabis derived from the effect of CBD, but it also adds the “high” which some people do not THC has very important therapeutic effects that are both noteworthy . One of the many reasons people take Hemp CBD is that it does NOT have the side effects!. If you're using CBD gummies to treat your anxiety and depression then you'll CBD works by affecting the body's endocannabinoid system, a system of may be effective for treating a problem on the surface, but the side effects Rest assured, CBD and THC have vastly different effects, and CBD is not psychoactive at all.