Cannabis Drug Shows Promise in Treating Schizophrenia · CBD as an antipsychotic drug Cannabis with high CBD content is associated with fewer psychotic. Aug 1, Learn more about CBD for schizophrenia. In other words, cannabis probably doesn't cause psychosis, but people with a family history of. Sep 5, Cannabis Compound May Help Reduce Symptoms of Psychosis of people who have conditions such as schizophrenia and bipolar disorder.
CBD with Psychosis? & help Schizophrenia Can
Cannabis contains over cannabinoids of which deltatetrahydrocannabinol THC is the most well known. This evidence base is still very much emerging though, and so far only a few good quality trials have been reported. On 26th Sep , Mental Health Question Time will be discussing the pros and cons of cannabis in relation to our mental health.
Get your FREE tickets here! Participants were assessed at baseline and treatment end. On average, participants were Baseline outcome measures were similar between groups. However, they found no impact on negative psychotic symptoms. Overall, these results suggest that CBD has an antipsychotic effect in schizophrenia when delivered as an adjunct treatment. However, this effect appears to be very modest and limited to only positive psychotic symptoms. This study was the first double-blind RCT to be published investigating CBD as an adjunct to existing antipsychotic treatment.
It is the largest trial of CBD as an antipsychotic in patients with schizophrenia so far reported. It also trialled a slightly higher daily dose than other studies 1, mg compared to mg. Retention was excellent with just one withdrawal from each group, which in both cases was due to adverse symptoms. It was an international study, which recruited participants across three countries, which helps with the generalisability of the results.
Overall this a high quality study that offers the best evaluation to date of the antipsychotic effect of CBD in patients. However, further and larger double-blinded trials are required to explore the replicability of these results. Importantly, the trial included participants who were already being treated with antipsychotic medication. Therefore the beneficial effects for CBD are in addition to those from existing treatment, suggesting that CBD may be a helpful adjunct therapy to current antipsychotic medication.
Evidence collected using a different study design is needed to investigate CBD as a standalone treatment. The primary limitation with the study design was its size. It was a phase two trial of a novel medication and such trials typically include hundreds of participants. So the study should at most be taken as an indication that CBD may have an antipsychotic effect arguably meriting further research, and not clear evidence that it does.
Another concern is about the modest benefit of treatment. Clinician rated improvement and wellness scores showed a minimal to moderate improvement in most cases. Other outcomes were not statistically significant. As such, this trial suggests that even if CBD may have antipsychotic properties as an adjunct treatment, they are small. This small trial is an indication that CBD may have an antipsychotic effect, but is not clear evidence that it does.
This study found that CBD appears to help improve positive psychotic symptoms and patient wellness. However, this is one of the first trials in this cohort.
Secondly, the benefits seen in this trial are modest while the other trial failed to find an effect, suggesting that CBD as an adjunct treatment provides at most a small benefit.
He also says that further complicating matters is that some research suggests there could be benefits from using CBD to treat psychosis. But at this point, he and his colleagues believe the risks outweigh any possible benefits. Further, for anyone tempted to try self-medicating with marijuana, both Foster and Dr. Manseau warn that what is available on the streets today is not the same as it was a few decades ago.
Manseau points out that this is worrisome since other studies show that using high THC marijuana increases the risk of psychosis. This makes it much more dangerous, especially for people who are susceptible to psychotic reactions. While most medical experts have studied the impact of cannabis on schizophrenia in others or have read the latest literature, Julie A.
She draws on her experiences as a person living with a mental illness to assist mental health professionals. Since she has first-hand knowledge of what it feels like to be psychotic, her insights are particularly helpful in teaching doctors how to support their patients when they are experiencing an episode. I see people as dangers to myself and am not able to process information in a normal way. He also says that some people believe that since they know marijuana with high THC is dangerous, they will just take more care with what they use [in terms of THC content].
I tried medical marijuana to manage this pain. And even with very careful use of the product, with all of my education and planning, I had the worst psychotic episode of my life. As the result of her own experiences, Fast points out that she strongly advises against using marijuana for people with schizophrenia.
I know that people are going to use it. Her program educates patients about the risks of marijuana and offers advice on how to navigate this dangerous territory in the safest way.
National Institutes of Health. National Institute on Drug Abuse. Is Marijuana Safe and Effective as Medicine? Accessed 20 September Mammen, G et al. A Systematic Review of Prospective Studies. Journal of Clinical Psychiatry. Iffland, Kirsten and Grotenhermen, Franjo. Risks and Therapeutic Potential. Accessed June 11, Accessed online April 20, Accessed May 2, Acute effects of smoked marijuana in marijuana smokers at clinical high-risk for psychosis: Psychiatry Research , ;
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While schizophrenia is a challenging illness to live with, with the right supports in place, one can still lead a happy, full. Mar 5, Indeed, there is evidence that THC can cause psychotic episodes immediately after using cannabis, some of which can persist after the effects. Sep 5, In a group of young people at high risk of psychosis, a single dose of cannabidiol reduced brain function Cannabis extract helps reset brain function in psychosis [press release]. Schizophrenia & Psychotic Disorders.