This phenomenon, called the entourage effect, results when the many components within the cannabis plant interact with the human body to produce a stronger. The entourage effect is a proposed mechanism by which compounds present in cannabis which are largely non-psychoactive by themselves modulate the. One of the hot phrases in the cannabis industry right now is the “entourage effect. ” Simply put, the thesis is that combining cannabis compounds.
Entourage Effect The
From that, many people have concluded that all of the synergistic effects are beneficial. So, is full-spectrum oil is always the best solution for cannabis medicine and consumer products? The quick answer is no.
Tailored cannabinoid formulations are far more effective and consistent, and will make up a large portion of mainstream adult cannabis consumption in the future. Over the last three years in our cellular pharmacology lab, we have studied the effects of individual cannabinoids and terpenes on receptor cells, and then measured the activity in those cells when in the presence of a formulation that combines two or more cannabis compounds. Like Mechoulam and Russo, we have found that different combinations result in quantitatively different reactions from the cells.
One compound magnifies the effect of another; another compound mitigates the effect of another. In full-spectrum consumption, different cannabinoids act on several different receptors in the human body at the same time. Worse, other cannabinoids can invoke the complete opposite of the desired result.
A report in Nature earlier in found that the cannabinoid content of legal cannabis in Washington state varies systematically across consumer products and even across testing facilities. Whole-plant consumption effectively throws an unknown and unquantified combination of cannabinoids at every receptor and hopes for the best. It is the ultimate in polypharmacology.
The other side of the coin is using a single cannabinoid to target a single receptor like CB-1 cannabinoid receptor 1 to perform a single activity. This is the approach taken by Big Pharma thus far, ignoring the entourage effect altogether. Neither extreme is ideal. But between these two poles lies the best way to truly take advantage of the entourage effect: Every day, cannabinoid scientists are identifying the unique effects of each cannabinoid and terpenoid, and the interactions between them.
In our lab we have shown that formulations produce consistent, reproducible physiological and psychological effects in humans. For patients and consumers, this means a repeatable, predictable, consistent reaction or experience. Using scientifically proven combinations is safer and more effective than pouring all of the compounds into your body at once, and that is the true value of the entourage effect.
As the body of scientific research grows, a more thorough understanding of the exact synergistic interplay among discrete cannabinoids and terpenes will lead to sophisticated harnessing of the entourage effect. This knowledge will drive the future of cannabis products, developed for specific patient and adult consumer needs and desires.
Jon Cooper is the CEO of ebbu , a multi-platform cannabinoid technology company that is redefining cannabis cultivation, transforming the supply line, and designing lab-tested medicinal and adult-use product formulations. Our goal is to simplify the process and make compliance as easy possible so that companies can focus on doing business.
It includes audit content for rules developed by the Nevada Department of Taxation. It also includes content for a growing number of local jurisdictions, including Las Vegas and Clark County. The platform also includes a feature that assists cannabis companies in developing standard operating procedures SOPs.
Plus, it gives managers the tools to easily hold staff accountable for their compliance responsibilities, providing peace of mind to owners. The Simplifya app was introduced in Colorado in late and expanded its services to include California in March of this year.
The primary effect of myrcene, another common terpene found in cannabis, is sedation. When myrcene is combined with THC, the result is a relaxed, sleepy high.
Some strains that have good amounts of myrcene include skunks, Himalayans and White Widow. Still other terpenes can activate other chemicals. Phytecs, a Los Angeles company researching the endocannabinoid system and how different cannabinoids and terpenes can be combined for therapeutic benefits, is researching terpenes that potentially can:. Future terpene research will focus on figuring out the effects of different combinations and ratios of cannabinoids and terpenes.
Juan Sanchez-Ramos, a neurology professor at the University of South Florida and the medical director for 3 Boys Farm, a licensed medical marijuana company in Florida.
Other areas of research include exploring whether the entourage effect is altered, depending on how cannabis is consumed. So, what is the entourage effect, and is it real? Phytecs, a Los Angeles company researching the endocannabinoid system and how different cannabinoids and terpenes can be combined for therapeutic benefits, is researching terpenes that potentially can: Quicken the onset of psychoactive effects. Prolong the duration of the therapeutic effects of cannabis.
Understanding the ‘Entourage Effect’
This interactive synergy between cannabis compounds has been coined the “ entourage effect,” and once you know what this is, you'll see why. Some call it the entourage effect: THC achieves its full effects only when it rolls with a crew of other compounds. They display unique therapeutic effects that may contribute meaningfully to the entourage effects of cannabis-based medicinal extracts. Particular focus will be.