MONDAY, May 7, (HealthDay News) -- Cannabidiol (CBD) oil has become the hot new product in Worse, CBD is being produced without any regulation, resulting in products that vary widely in . Top causes and how to find relief. Feb 26, This quality makes CBD an appealing option for those who are looking for relief from pain and other symptoms without the mind-altering effects. Jan 7, The cannabis plant component is wildly popular – and misunderstood.
We have now entered a time where the benefits of this plant are beginning to come back to the forefront of the discussion. Indeed, countless individuals across the world have access to legal marijuana for chronic pain conditions. Should patients turn to singular compounds found in the plant, or turn to the plant itself? If using the whole plant, what marijuana strains are the best for providing relief from pain?
When you compare Western medicine to traditional medicine the world over, one of the most striking differences is the need in the West to pinpoint one specific molecule that is responsible for treating a disease or symptom. This viewpoint stands contrary to the idea of holistic medicine, where you take something in its entirety for medicinal purposes. The Cannabis sativa plant is one of the greatest present-day examples of this tug-of-war between Western medicine and traditional medicine.
It has been found to have a variety of health-related benefits for the user. CBD is the second most well-known cannabinoid found in cannabis, and like most of the other phytocannabinoids, it is non-psychotropic. These are the two most abundant and well-studied cannabinoids in marijuana, and both have been found in numerous published studies to have pain-relieving properties in humans. While they may be the most abundant, THC and CBD are certainly not the only compounds found in cannabis that are known to exert positive effects on human health.
In every cannabis plant, there is a unique mixture of hundreds of plant compounds, comprised of phytocannabinoids, terpenes, and flavonoids.
Research suggests that these compounds too have an influence on our neurochemistry, and together they may work synergistically, producing better improvements in pain relief than anyone would produce on its own. This research supports the idea that it is best to use the whole cannabis plant, with CBD, THC, and the natural medley of additional compounds.
This harmony between the various plant chemicals found in marijuana is colloquially referred to as the entourage effect. The most well-studied compounds found in the marijuana plant that support the idea of the entourage effect are THC and CBD, which have been found to work differently together than when separate. Using these two compounds in concert has been shown to help mitigate side effects and enhance efficacy, with CBD plus THC showing more benefit for some conditions than THC alone.
It has also been found to extend the half-life of THC, which may help to extend the pain-relieving benefits. This has allowed the use of higher doses of THC in clinical trials for the treatment of pain caused by multiple sclerosis, peripheral neuropathic pain, intractable cancer pain, and rheumatoid arthritis.
When used in concert, a greater efficacy in treating these types of pain have been observed. Every strain of bud that you can purchase at a dispensary will be labeled with its THC and CBD content, which can be helpful when choosing which strain to choose for pain relief. CBD has been found to exhibit enhancements in treating pain both when used on its own and when used in combination with THC. When used alone, CBD is largely best for inflammatory pain, such as that caused by arthritis or injuries.
In one animal study on arthritis pain, it was found that the topical application of CBD led to a reduction in inflammation and pain. Another animal study found that CBD helps to reduce neuropathic pain through the suppression of chronic inflammation.
CBD does not directly bind to the receptors found in the endocannabinoid system but rather works to modulate the effects of the endocannabinoids the cannabinoids found naturally in our bodies as well as working as a CB1 receptor antagonist.
The main mechanism by which CBD is thought to help mediate pain is by reducing inflammation , largely by blocking inflammatory mediators. It is also believed to potentiate glycine receptors, which help to regulate pain at the spinal level. This suppresses both neuropathic and inflammatory pain. THC is used clinically for the treatment of pain and studies find it helps relieve central and neuropathic pain. It is also used to help reduce pain in cancer, AIDS, and fibromyalgia patients, for which resistance to other pain treatments have been found.
The mode of action for THC is as a partial CB1 receptor agonist, which means that it will bind to these receptors but not fully which leads to the variability in effects documented when THC is present with other CB1 agonists, antagonists or both. It has been found to impact the serotonergic, dopaminergic, and glutamatergic systems — an action which may contribute to its pain-relieving benefits.
Additionally, THC has been found to act as an anti-inflammatory agent. While human studies have found benefits from the use of THC, CBD, and whole-plant marijuana in relieving pain, much of the evidence for this use comes from user reports and surveys. When searching for the best cannabis strains for pain relief, you will first want to consider how much THC and CBD is found in the strain.
This is because CBD can help to mediate the side effects of THC while also providing additional anti-inflammatory and analgesic properties. One example would be if you are experiencing inflammation, yet you are wanting to go about your day normally, without the psychotropic effects of THC. Other times you may be in enough pain that you would like something that takes your mind off the pain while also offering pain relief. In one survey , participants reported that indicas helped more than sativas when it came to headaches, joint pain, neuropathy, and spasticity.
Users also reported indicas to be more helpful when it comes to sleep and sedation. Lastly, there are countless user reports on specific strains of weed that have been found to be powerful for relieving pain. While some of these strains are high CBD, indica strains, some strains of weed used for pain do not fall into this category.
It may be that the other cannabinoids, terpenes, and flavonoids have come together in a harmonious balance that leads to strong pain-relieving properties. Doctors will want to monitor the person for any changes and make adjustments accordingly. The patient information leaflet for Epidiolex cautions that there is a risk of liver damage, lethargy, and possibly depression and thoughts of suicide, but these are true of other treatments for epilepsy, too.
One study in Frontiers in Pharmacology , suggested cannabinoids' anti-inflammatory effect may reduce inflammation too much. A large reduction in inflammation could diminish the lungs' defense system, increasing the risk of infection. Almost all research on CBD oil and pain comes from adult trials. Experts do not recommend CBD oil for use in children, as there is little research on the effects of CBD oil on a child's developing brain. While many studies have suggested CBD oil is helpful for pain, more research is necessary, especially in long-term studies with human subjects.
However, CBD oil does show a lot of potential for pain relief. Anecdotal evidence suggests that it can be used to help manage chronic pain in many cases. CBD oil is especially promising due to its lack of intoxicating effects and a possible lower potential for side effects than many other pain medications.
People should discuss CBD oil with their doctor if they are considering using it for the first time. CBD oil is available for purchase online. CBD oil is legal in the U. Users should follow legal channels to obtain the CBD. The science is emerging to support its use, especially in a time where most people want to avoid the addicting opioids in chronic pain.
Because of the changes in social acceptance for the use of the marijuana plant and the urgency to address the opioid crisis, there is funding for clinical trials. A study found CBD was effective for chronic neuropathy pain. It may have a role in reducing inflammation as well. The individual should talk to a doctor first, start with the lowest doses possible, read the information available, and be an informed consumer.
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Receptra Naturals offers premium organic, whole plant, pure hemp extracts for sale in all 50 States. Article last updated by Adam Felman on Fri 16 March All references are available in the References tab.
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Cannabidiol reduces cigarette consumption in tobacco smokers: Addictive Behaviors, 38 9 , 2,, Keep reading to learn more about CBD oil, how it works, and how it can help manage chronic pain. Plants like hemp or cannabis have different levels of compounds inside them.
So the way a person breads the plant affects the level of CBD. Companies that make CBD oil all have their own way of doing it. Apart from their own varieties, the basic process involves extracting the compounds from the plant and adding them to a carrier oil. You can find CBD oil in many different levels of strength, and some oils are designed for specific uses.
Like any other medication, you should always talk to your doctor before trying CBD oil for yourself. For example, studies show that CBD interacts with both your immune system and your brain receptors. These receptors receive a bunch of chemical signals from stimuli and help the rest of your cells respond to those signals. When your receptors react with CBD, they form anti-inflammatory effects that reduce pain. CBD also helps treat conditions like anxiety, depression, fibromyalgia, and stress.
This makes CBD oil an effective treatment option for a multitude of medical conditions. But one of the biggest benefits of CBD oil is that it can help relieve symptoms of chronic pain. Because CBD interacts with the receptors in your brain, it improves your pain management system.
That means any inflammation goes down and the pain itself lessens. You can continuously take CBD oil for your chronic pain and not build up a tolerance for it. In other words, CBD oil provides a long-term option for a long-term problem. This makes CBD oil an effective treatment for all types of chronic pain, including conditions like arthritis. But there are some other ways to find out for yourself. You should start by asking yourself two important questions.
Prescription drugs can be expensive.
CBD Pain Relief: How CBD Works to Manage Chronic Pain
Oct 19, CBD stands for cannabidiol, one of the major constituents of cannabis. CBD products are made from industrial hemp and come in various. Mar 16, People using CBD oil for arthritis may find relief from their pain, but more human studies need to be done to confirm these findings. Dec 5, Cannabidiol - also known as CBD - is currently taking the UK by storm, thanks to its wealth of health benefits. One of these is pain relief: studies.