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effects Endocrine gain) glycemic and (including appetite, weight

truxanul
28.09.2018

Content:

  • effects Endocrine gain) glycemic and (including appetite, weight
  • A Review of Weight Control Strategies and Their Effects on the Regulation of Hormonal Balance
  • Alternative names for hypopituitarism
  • Several of these circulating appetite modulators, including ghrelin, the only This, combined with the lack of expected corresponding leptin-mediated effects, has given rise The GI tract is the largest endocrine organ in the body and is . Weight gain prevention through pre-prandial receptor blockade may. The postprandial endocrine response associated with meals of varying [20] reported that an increase of protein from 15% to 30% of dietary intake resulted in Acute effects of dietary fibre and glycaemic carbohydrate on appetite and food. via hypoxia-induced reductions in appetite and weight gain. Life Under Hypoxia Lowers Blood Glucose Independently of Effects on Appetite and Body Weight in 1Division of Endocrinology & Metabolism, Department of Medicine III, Factors that may affect the outcome include, e.g., differences in the.

    effects Endocrine gain) glycemic and (including appetite, weight

    The area postrema AP and nucleus tractus solitarii NTS in the brainstem convey these peripheral signals, consisting of nutrients, hormones and vagal afferent activation, to the arcuate nucleus ARC of the hypothalamus Bailey In this process, the hypothalamus acts as a gatekeeper, as it additionally controls body temperature, energy expenditure and glucose metabolism.

    In normal physiology, the integration of all peripheral signals will result in energy intake matching the organism's energy expenditure. The homeostatic signals arising from peripheral organs convey different aspects of the energy regulatory process to the CNS: In normal physiology, central leptin signalling has an anorectic effect Cohen et al.

    Thus, insulin may relay both long-term and acute information and was shown to act in the brain to reduce food intake Woods et al. In obesity and over-nutrition, peripheral insulin resistance results in chronic hyperinsulinaemia. Interestingly, a study using fluoro-deoxy-glucose 18 FDG positron-emission tomography PET indicated the existence of central insulin resistance in obese individuals with the metabolic syndrome, which is compatible with the generally greater caloric intake in these individuals Anthony et al.

    In contrast to homeostatic control of feeding behaviour, non-homeostatic feeding behaviour is not regulated by hunger and satiety signals but rather by the rewarding properties and motivation related to foods, and involves reward, cognitive and emotional factors.

    Thus, corticolimbic circuits in humans including the striatum, amygdala, insula, nucleus accumbens NAc and orbitofrontal cortex are implicated in non-homeostatic eating. Within the CNS, pathways for homeostatic and non-homeostatic control of feeding comprise multiple interconnected brain regions. The above-described hormonal regulators of homeostatic feeding may also influence brain reward systems and may increase or decrease the rewarding value of food depending on energy requirements Berthoud , Kenny Palatable food can activate brain reward circuits, and these rewarding effects can be a powerful motivation for food consumption and may overrule signals regulating homeostatic feeding.

    The studies summarised above show that both homeostatic and non-homeostatic factors influence feeding behaviour and that there is an extensive cross-modulation of signals within these pathways.

    Although not approved for the treatment of obesity, administration of GLP-1RA consistently results in body weight loss in humans. Following meal ingestion, GLP-1 is secreted into the circulation by enteroendocrine L-cells located in the distal jejunum and ileum and contributes to postprandial glucose regulation, as it augments meal-related insulin secretion from the pancreas Kreymann et al.

    Also GLP-1 promotes insulin gene transcription Drucker et al. Other glucose-lowering mechanisms of GLP-1 involve inhibition of glucagon secretion and deceleration of gastric emptying and gut motility.

    In addition to pancreatic islets, GLP-1 receptors have been demonstrated in the gut, heart, vasculature, kidney, muscle and lung Sivertsen et al. Exenatide, the first GLP-1RA developed for human use, is a synthetic form of exendin-4, a amino acid peptide isolated from the salivary secretions of the Gila monster Heloderma suspectum.

    Substitution of alanine by glycine at the second position of the NH 2 -terminus makes exendin-4 resistant to DPPmediated degradation Nielsen et al. Exenatide is currently available in two formulations for the treatment of T2DM, i.

    Consequently, liraglutide is suitable for QD administration. An important determinant of postprandial hyperglycaemia is the rate of gastric emptying.

    Rapid tachyphylaxis of gastric emptying deceleration, resulting from continuous stimulation of the GLP-1 receptor by long-acting but not short-acting GLP-1RA, may explain their lack of efficacy with respect to meal-related hyperglycaemia Nauck et al.

    The occurrence of these side effects may limit the possibility of higher dosing of GLP-1RA and possible greater improvement of glycaemic control and body weight reduction. As an additional benefit, treatment with GLP-1RA is associated with sustained dose-dependent weight lose.

    In trials comparing exenatide BID, exenatide QW or liraglutide with basal or biphasic insulin, thus achieving similar glycaemic control in both intervention groups, the weight differences were even more prominent. In phase-3 trials, weight loss effects of lixisenatide were relatively modest up to a mean of 1.

    Weight changes from baseline to 20—30 weeks during phase-3 trials no extension trials comparing approved GLP-1RA with placebo or insulin in T2DM patients and obese non-diabetic individuals. The observed GLP-1RA-related weight loss was associated with reduction in total body fat, particularly trunk or visceral fat Jendle et al.

    Although open-label extension trials with GLP-1RA may be flawed by selection bias towards responders, the observed sustained weight loss over time seems different to weight loss through dietary restriction, where only a small minority of obese individuals maintain weight loss in the long term Anderson et al. It is worthy of note, however, that when exenatide BID was discontinued after 3 years of exposure, patients started to regain weight during the week washout period Bunck et al.

    In non-diabetic obese individuals, placebo-adjusted weight loss after week treatment with liraglutide, at doses of 1. It is worth noting that, currently, GLP-1RA have not been officially approved for the treatment of obesity. To attain body weight loss, achieving long-term negative energy balance by reduction in appetite and energy intake, or by an increase in energy expenditure or both is required.

    Preclinical data indeed show an inhibiting effect of GLP-1 administration on food intake. Also in humans, GLP-1 was shown to reduce food intake, appetite, and hunger and to promote fullness and satiety Flint et al. It is noteworthy that satiation and satiety are commonly used as synonyms, but need to be distinguished Mithieux Satiation is the increasing sensation of fullness that occurs during digestion and absorption of a meal. Satiety is a state of no-hunger that occurs some time after the last meal and moderates the initiation of the following meal.

    A placebo-controlled study in healthy normal-weight individuals investigating the effects of i. However, there were no differences in the subjective ratings of taste, visual appeal, smell, aftertaste and overall palatability of the meal. Similar reductions in hunger and increases in satiety scores were described in studies with a similar design in obese and T2DM individuals Naslund et al.

    In a meta-analysis of studies in humans evaluating acute effects of GLP-1 infusion on food intake, a mean decrease of However, at the latter GLP-1 concentration, there were no statistically significant effects on ad libitum food intake. Studies observing prolonged GLP-1 administration over more than one day are limited.

    Two small studies, using a continuous s. Furthermore, a hallmark proof-of-concept study, during which GLP-1 was administered via continuous s. Taken together, these observations regarding food intake in humans show that GLP-1 administration has consistent acute effects on hunger, fullness and satiety measures. Longer-term studies in small groups indicate that a persistent reduction in appetite and food intake may mediate the effects of GLP-1RA treatment on body weight. The body-weight-reducing effects of GLP-1RA treatment could also be due to increased energy expenditure, leading to a negative energy balance.

    However, the reported effects of GLP-1 on energy expenditure from animal data are not consistent. Energy expenditure depends on oxidation of substrates and consists of different elements, such as resting metabolic rate, physical activity and thermogenesis. In contrast, acute i. Furthermore, 4 week i. More specifically, GLP-1 seems to affect thermogenesis. The effect of GLP-1 on body temperature was not altered by decerebration, whereas cervical spinal transection attenuated the thermogenic response to GLP-1 Osaka et al.

    Interestingly, BAT thermogenesis changes did correlate with an increased activity of sympathetic fibres innervating BAT. Taken together, these preclinical findings indicate that GLP-1 might have effects on the central regulation of energy balance by affecting energy expenditure and specifically thermogenesis, but the results are not fully conclusive.

    In humans, the reported effects of GLP-1 on energy expenditure are more inconsistent. During acute GLP-1 infusion, energy expenditure caused by diet-induced thermogenesis was decreased in both healthy lean and obese individuals Flint et al. Given the lack of consistency in the effects of GLP-1 and GLP-1RA on energy expenditure in humans, it has been concluded that the treatment-related body weight loss can rather be attributed to a decrease in energy intake.

    Various mechanisms and routes of action of GLP-1 are involved and contribute to the inhibitory effect on food intake. An important factor in the regulation of appetite and satiation during food intake is gastric mechanosensation. Distension of the stomach induces satiation signals by activation of gastric mechanoreceptors, which relay information via vagal nerves to the NTS in the brainstem.

    The amount of gastric distension due to food intake is partly influenced by the rate of gastric emptying, which affects postprandial glycaemic excursions. GLP-1 delays gastric emptying and gut motility not only in healthy lean but also in obese subjects and patients with T2DM Nauck et al. Delayed gastric emptying affects the extent of gastric distension, the rate of nutrient exposure of the gut and, consequently, gut hormones secretion, which in turn influences postprandial glucose excursions.

    Although usually transient, gastrointestinal symptoms, most notably nausea and occasional vomiting, are the most commonly reported side effects during GLP-1RA treatment.

    One might speculate that changes in signalling due to delayed gastric emptying and nausea are the sole cause of GLPinduced changes in appetite and satiation and of GLP-1RA treatment-induced weight loss. In rodents, acute infusion with GLP-1RA induced a delay in gastric emptying, associated with a decrease in food intake. However, after 14 days of continuous GLP-1RA infusion, gastric emptying was similar to that of animals receiving a vehicle infusion, but food intake was still reduced Jelsing et al.

    Also in humans, the inhibitory effect of GLP-1 on gastric emptying is subject to tachyphylaxis Nauck et al. In spite of the observed tachyphylaxis of delayed gastric emptying, the weight-lowering effect of GLP-1RA treatment persists over periods up to 3 years Macconell et al. Other observations making it less likely that GLP-1RA effects on gastric emptying are the only cause of appetite and weight loss include the observed weight reduction during GLP-1RA treatment in the absence of nausea Buse et al.

    Taken together, other mechanisms than delayed gastric emptying alone contribute to the appetite-suppressing effect of GLP-1RA treatment. Proposed routes of action of GLP-1 in the central regulation of feeding and glucose metabolism. Gut-derived GLP-1 may affect the brain by several routes of action, i. Other potential mediators constituting the gut—brain axis include nutrients and signals arising from meal-related gastric distension.

    GLP-1 secreted from intestinal L-cells in response to meal-ingestion, diffuses across the basal lamina into the lamina propria, at which level the uptake by capillaries and the degradation by DPP-4 occurs. Subsequently, endogenous GLP-1 activates intestinal vagal afferents, located in the gut or portal circulation, partly belonging to the enteric nervous system ENS , which may activate GLPproducing neurons in the nucleus tractus solitarii NTS.

    Additional activation of intestinal or portal vagal afferents by nutrients, other gut-hormones or gastric distension may also activate these GLPproducing neurons. These neurons project to several food-regulating areas, most of which contain GLP-1 receptors. To date, no receptors have been found in the ventromedial hypothalamus VMH. Less is known about the higher cortical centres that extend the circuitry beyond the hypothalamus, VTA and nucleus accumbens.

    Efferent pathways, among others, originating in the brain stem BS , subsequently signal to peripheral organs to close the loop of feeding behaviour and glucose metabolism regulation, both of which may be partly interlinked. Accordingly, GLP-1 lowers blood glucose by stimulating pancreatic insulin secretion and production, and by suppressing glucagon secretion from the pancreas and by enhancing hepatic insulin action in a glucose-dependent manner. Also, GLPrelated effects promoting gastric emptying delay seem to be part of this regulatory loop.

    These actions may be due to direct effects of circulating gut-derived GLP-1 but, given the short circulating half-life of the incretin hormone, indirect, neurally mediated effects may contribute, even to a greater extent, to the efferent output to these organs. Journal of Endocrinology , 1; Experimental data indicate that GLP-1 may also exert actions in the brain beyond these well-established effects, by influencing neuronal health, cognition and neuro-inflammation During et al.

    Imagine what goes on in a cortisol-flooded, stressed-out body when food is consumed: Digestion and absorption are compromised, indigestion develops, and the mucosal lining becomes irritated and inflamed. This may sound familiar. Ulcers are more common during stressful times, and many people with irritable bowel syndrome and colitis report improvement in their symptoms when they master stress management.

    This is advantageous for fight-or-flight situations but not perpetually. Over time, such arterial constriction and high blood pressure can lead to vessel damage and plaque buildup—the perfect scenario for a heart attack.

    This may explain why stressed-out type A and the newly recognized type D personalities are at significantly greater risk for heart disease than the more relaxed type B personalities. Fertility Problems Elevated cortisol relating to prolonged stress can lend itself to erectile dysfunction or the disruption of normal ovulation and menstrual cycles.

    Furthermore, the androgenic sex hormones are produced in the same glands as cortisol and epinephrine, so excess cortisol production may hamper optimal production of these sex hormones. Other Issues Long-term stress and elevated cortisol may also be linked to insomnia, chronic fatigue syndrome, thyroid disorders, dementia, depression, and other conditions.

    Assessing Cortisol Levels The adrenal stress index ASI , a salivary test, is the preferred test for adrenal function and a well-accepted, noninvasive, reliable indication of cortisol levels. The ASI is available as a home kit. Four saliva samples are taken at specific times and then shipped to a laboratory for analysis. Conveniently, in addition to measuring the adrenal hormones cortisol and dehydroepiandrosterone, the same test also measures antibodies to gliadin, often used as a marker for intestinal inflammation, Candida infections, and sensitivity to gluten-containing grains.

    Note that this test cannot diagnose gluten sensitivity definitively. A blood cortisol test is available, but it is considered inferior to the salivary test for three reasons: It tests cortisol levels only at one given point in time, which provides less information than levels at four times which reveals important imbalances ; the blood test itself or simply going to the doctor can stress a person enough to cause a cortisol surge; and it is considered less sensitive because it measures the total hormone level as opposed to specific components.

    The Good News So far, it may seem as though stressed-out folks are destined for failed health despite their best intentions.

    Fortunately, there is much we can do for our clients and ourselves to reverse the path of destruction. The best approach to keeping cortisol levels at bay is mastering stress management and optimizing diet. Stress Management First, regardless of our scope of practice, we can always recommend strategies for effective stress management. Minimizing stress may require a team approach; we can acknowledge its importance and leave the details to the experts.

    The Anti-Inflammatory Diet Systemic inflammation, as noted previously, causes elevated cortisol levels. If we can naturally decrease inflammation in the body and minimize stress, decreased cortisol levels should follow, resulting in decreased chronic disease risk and improved wellness. The biochemical processes leading to and abating inflammation are complex and multi-faceted, but as experts in diet and lifestyle, we can make a significant difference.

    Like any diet designed to manage a condition, there is no one perfect anti-inflammatory diet. However, based on known properties of foods and clinical research, we can devise a generally low-inflammatory diet and tweak it over time. Obviously, maximizing the anti-inflammatory foods and minimizing the proinflammatory ones is a big step toward controlling inflammation.

    Incidentally, dietary strategies for controlling inflammation may also help with adrenal support in general, since diet can directly affect adrenal burden eg, cortisol is released in response to metabolic demands. Clearly, these are merely guidelines. Note that while medications such as nonsteroidal anti-inflammatory drugs temporarily alleviate inflammation, hundreds of studies have demonstrated that long-term use can cause damage over time and even exacerbate systemic inflammation.

    Summary Cortisol is a fascinating hormone that is important to nutrition science on many levels. Understanding the science behind it, including its behaviors and relationships to other biochemical components, the immune system, and health outcomes, is crucial to our success in treating people who seek dietary intervention for stress, illness, fatigue, and other common complaints.

    Implementation of targeted dietary and lifestyle approaches is an extremely powerful way to reduce stress, minimize inflammation, and reduce the risk for illness and chronic disease. True, the many biochemical processes involving cortisol and other hormones, stress, and inflammation and their impact on health and disease risk are complex and elaborate. The therapeutic diet and lifestyle strategies, however, are not. Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance.

    J Clin Endocrinol Metab. Stress and body shape: Stress-induced cortisol secretion is consistently greater among women with central fat. Stress may add bite to appetite in women: A laboratory study of stress-induced cortisol and eating behavior. Jones DS, Quinn S eds. Textbook of Functional Medicine. Institute for Functional Medicine; The heart, stress, and cortisol.

    The measurement of hormones in saliva: A better measure of adrenal cortical function than serum cortisol.

    A Review of Weight Control Strategies and Their Effects on the Regulation of Hormonal Balance

    This review examines the physiologic effects of glycemic index and argues for the need , Ludwig et al a, Nicklas ), and weight loss with An increase in carbohydrate intake has in fact been observed in the U.S. since . To explore the physiologic events that might relate GI to appetite, we. Hormone balance starts with your gut and what you eat. Changes in the levels of your thyroid hormones will impact your: energy levels diabetes; high estrogen levels; weight gain; appetite changes; reproductive problems . Aim to eat a low-glycemic diet that includes lean protein and healthy fats. Weight gain was associated with improved glycemic control in both studies. a direct effect on receptors in the central nervous system that govern appetite. .. Kersten KS: Mechanisms of nutritional and hormonal regulation of lipogenesis.

    Alternative names for hypopituitarism



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    yoko19881

    This review examines the physiologic effects of glycemic index and argues for the need , Ludwig et al a, Nicklas ), and weight loss with An increase in carbohydrate intake has in fact been observed in the U.S. since . To explore the physiologic events that might relate GI to appetite, we.

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