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Muskelmasse allmax nutritionKentrecipient of the Prelog Medal, was steriid in New Zealand in After earning a B. Inhe joined the faculty of the University of Chicago, where he is currently Professor of Chemistry, Biochemistry and Molecular Biology. Over the past four decades, Stephen Kent has profoundly shaped the field of peptide and protein chemistry. His many and diverse contributions have altered the way scientists tackle the production of these biomacromolecules.
Kent , recipient of the Prelog Medal, was born in New Zealand in After earning a B. In , he joined the faculty of the University of Chicago, where he is currently Professor of Chemistry, Biochemistry and Molecular Biology. Over the past four decades, Stephen Kent has profoundly shaped the field of peptide and protein chemistry. His many and diverse contributions have altered the way scientists tackle the production of these biomacromolecules. Preparation of the amino acid long HIV protease and its enantiomer using optimized protocols for solid-phase peptide synthesis, to cite only one example, was a signal achievement.
This work, together with follow-up studies, convincingly demonstrated that total chemical synthesis is a viable and practical alternative to protein biosynthesis, capable of providing large quantities of material for detailed mechanistic and structural studies. Methods for coupling unprotected peptide fragments have been even more influential. Since its introduction in , native chemical ligation has become a robust, reliable and widely used technology.
Some of its most exciting applications include selective labeling of individual protein domains for spectroscopic studies and incorporation of unnatural amino acids or novel backbone modifications into the target sequence. Efficient total chemical synthesis of human insulin, fully active glycoprotein mimetics of erythropoietin, and many mirror image protein molecules highlight the practical utility of such approaches.
As these examples attest, Stephen Kent has had a gift, throughout his career, for pioneering new chemistries, and for utilizing them to reveal the molecular basis of protein function. Not surprisingly, he is much-recognized for exceptional achievement. Among other major distinctions, he has received the Hirschmann Award in Peptide Chemistry , the E.
The Laboratorium für Organische Chemie is honored to add his name to the roster of distinguished Prelog medalists. Born in in Malung, Sweden, Prof. Following a position at Massachusetts Institute of Technology as a research associate with Prof.
Sharpless, he was appointed as an assistant professor at the Royal Institute of Technology in Sweden Kungliga Tekniskahögskolan. He rapidly rose through the ranks to the level of associate professor at the same institution. In he was appointed as Professor of Organic Chemistry at Uppsala University, and in he moved to Stockholm University where he holds an appointment as Professor of Organic Chemistry.
His research interests span a wide range to include bio and chemo —catalysis. During the early part of his career, Prof. Bäckvall conducted pioneering experiments in Palladium-catalyzed olefin difunctionalization. The work is prominent because of its importance as a preparative approach to useful building blocks as well as the deep mechanistic insight it offers into metal-mediated reactions of alkenes, such as the Wacker oxidation.
These classic experiments brilliantly rely on the design of stereochemical reporter groups to enable meaningful interpretation of reaction mechanism. A significant outcome for preparative chemistry was the understanding of how variations in reaction conditions and catalyst employed lead to controlled, divergent formation of diastereomeric products.
Bäckvall has pioneered a visionary approach to reaction processes for asymmetric synthesis that combine chemical and bio catalysis. The processes he has devised define the standard for the production of optically active alcohol derivatives through dynamic kinetic resolution.
In the chemoenzymatic process, the biocatalysts perform the task of selectively esterifying one of the alcohol enantiomers while the metal catalysts are independently engaged in rapid epimerization of the alcohol mixture via redox processes. This has enabled the design of systems in which enzyme and metal catalysts are co-immobilized in compartments of mesoporous silica for cooperative tandem catalysis.
Professor Bäckvall has established a visionary research program with stereochemistry at its heart. Accordingly, he is richly deserving of the Prelog Medal Dervan in recognition of his outstanding research in chemical biology, with special emphasis on molecular recognition of double helical DNA by small molecules and their use in biological applications. Professor Dervan was born June 28, in Boston and received his undergraduate degree in Chemistry in at Boston College.
He obtained his Ph. Berson investigating thermal rearrangements and the limits of orbital symmetry rules. His thesis on the four-pathway analysis of the 1,3 sigmatropic rearrangement was considered a classic in the field. There he broadened his research horizons beyond physical organic to synthetic chemistry, especially applied to nucleic acids. Dervan was promoted to Professor of Chemistry in and since he has been the Bren Professor of Chemistry.
His most significant contribution was the experimental determination of the relative rates of rotation, cleavage, and closure of the parent 1,4-biradical, tetramethylene.
His demonstration of the 1,4-biradical as a common intermediate generated from different precursors was considered an experimental tour de force. Dervan made a decision in the s to move research from studies of reactive intermediates to understanding the ensembles of weak interactions underpinning molecular recognition in water.
He believed the frontier was to understand molecular recognition in aqueous systems, the solvent of life, and probe macromolecular targets important in biology such as nucleic acids and proteins. His major contribution was studies directed toward understanding the chemical principles for the sequence specific recognition of double helical DNA.
Dervan and his coworkers brought the power of synthetic chemistry and the logic of incremental change to molecular recognition in biological systems. He is considered an early pioneer of the field of chemical biology. Peter Dervan has served on several Scientific Advisory Boards for the pharmaceutical and biotechnology industries. He was a member of the Board of Directors of Beckman Coulter He has served on several editorial advisory boards over the past 40 years.
Professor Dervan is an outstanding teacher, having received several teaching awards given by the undergraduate students at Caltech over three decades. Professor Meijer was born in April in Groningen and received his undergraduate degree in Chemistry in at the University of Groningen. From the same University, he obtained his PhD degree in , under the supervision of Professor Hans Wynberg, investigating the chemiluminescence of 1,2-dioxetanes.
He started his career at the Philips Research Laboratories in Eindhoven were he was active as a research scientist in the field of functional organic materials, including conducting and semi-conducting polymers. At DSM, he developed the synthesis of poly propylene imine PPI dendrimers, which were produced in large quantities and became commercially available.
In , he was also appointed as a Professor in the newly established Department of Biomedical Engineering. Two companies have started as spin-offs from his research: SyMO-Chem was founded in as a professional research contract company, while SupraPolix, founded in , focuses on supramolecular polymers. Bert Meijer is a leader in dendrimer chemistry. After moving to Eindhoven University of Technology, he demonstrated in for the first time the potential of PPI dendrimers as host containers, so-called dendritic boxes for small molecule guests, opening up the use of dendrimers as delivery systems.
He also investigated dendritic supramolecular self-assembly, showing in that amphiphilic block-co-polymers incorporating polystyrene dendrimer blocks undergo generation-dependent aggregation.
In , he pioneered the field of supramolecular polymers in which the repeat units, self-complementary monomers, are not connected by covalent bonds, but rather through quadruple hydrogen bonding. This opened up major academic and industrial research on reversible, self-healing polymers. In , he investigated pathway complexity in supramolecular polymerization processes.
He reported in helical self-assembled polymers from cooperative stacking of hydrogen-bonded pairs. He conducted profound investigations on the mechanisms of chemical self-assembly and demonstrated in the importance of solvent-assisted nucleation pathways for the formation of self-assembled systems. In , he also investigated the "Sergeants-and-Soldiers" principle for cooperative chiral self-assembly, when he found that an enantiopure discotic monomer at low concentration the "Sergeant" induces and amplifies columnar assembly of achiral discotic monomers "Soldiers" into helical discotic stacks of one preferred handedness.
His work has led to near publications and is highly cited. He holds many patents, such as on the preparation of PPI dendrimers. Cope Scholar Award in He was chosen in as the best teacher of the year at Eindhoven University of Technology.
After post-doctoral studies at Columbia University and a stay at Harvard University, he was appointed in to the Francis W. Bergstrom Chair in Chemistry at Stanford University. His name and work is synonymous with science that is both visionary and scholarly.
His is a line of inquiry that defies definition along the traditional disciplinary boundaries and instead amalgamates reaction discovery, target oriented synthesis, chemical and molecular biology, along with human medicine in a fully integrated research program. Interest in complex natural products chemistry provides the initial spark for methods development; in parallel they also provide launching point for the study of biological processes and the subsequent inspiration for the synthesis of designed, functional molecules.
Activities in target-oriented synthesis take on a broader goal in which strategic and tactical discoveries in synthetic chemistry enable advances in allied sciences. Professor Wender has coined the term function-oriented synthesis to capture the essence of the concept.
His vision inspires the next generation of chemists interested in evolving the field so that it remains vibrant and essential to the scientific enterprise and society at large. Professor Wender is a founding member, scientific advisor and board member of CellGate, a biotech company that pioneered new strategies for drug delivery, and is currently involved with several organizations advancing novel therapies developed in his laboratories.
He has been recognized with the highest honors in the profession, includinging membership in the National Academy of Sciences and the American Academy of Arts and Sciences. At the level of reaction discovery, Professor Wender can be credited with inventing an entire class of paradigm-changing ring-forming reactions.
His unique ability to innovate at the interface of organometallic and organic chemistry has enabled innovative metal-catalyzed cycloadditions. These advances have emanated from a prolific, scholarly research program that aims to identify novel reactivity to enable unprecedented bond constructions.
Professor Wender is responsible for the completion of monumental synthetic targets, including phorbol, taxol, resiniferatoxin, and prostratin. The sheer structural and stereochemical complexity of the natural products Wender selects for study renders them a challenge beyond the capabilities of most synthetic groups. In each case Professor Wender has devised syntheses that are notable because of their strategic elegance and the tactical implementation of cutting edge developments in synthetic methods.
He has been critical in crafting theoretical formulations to assess the evolution of the field of complex molecule synthesis, providing metrics for the ideal synthesis. In essence these make the compelling case that synthetic chemists should settle for nothing less than the very best in the development of exceptionally efficient reaction processes and strategies.
Professor Wender has been leading a revolution in the chemical sciences over the course of his career. His integration of chemistry, biology, and medicine with ground-breaking chemistry provides a guiding light for the direction of organic synthesis.
Thematically it provides a blueprint for a bright, relevant future for chemistry as a central science, with a leitmotif of stereochemistry throughout his career. It is fitting that in recognition of his innovation, scholarship, and leadership in the field Professor Wender is chosen as the recipient of the Prelog Medal.
Professor Rebek was born in Beregszasz, Hungary in and lived in Austria from He and his family then settled in the U. He received his undergraduate education in Chemistry at the University of Kansas in and obtained the Ph. In July of , he moved his research group to the Scripps Research Institute in La Jolla, California, to become the Director of The Skaggs Institute for Chemical Biology, where he continues his research in molecular recognition and self-assembling systems.
At the early stages of his career at UCLA, Professor Rebek developed the three-phase solid-liquid-solid test as an elegant mechanistic tool to demonstrate the formation of unstable reactive intermediates, such as monomeric metaphosphate and cyclobutadiene.
At Pittsburgh in the early s, he reported the first efficient synthetic allosteric receptor systems. With the development, in the mid 80ies, of highly preorganized cleft-type receptors composed of two suitably spaced Kemp triacid derivatives, and the application of the concept of convergent functional groups, Professor Rebek laid the groundwork for vigorous molecular recognition studies that dominated worldwide physical-organic chemistry in subsequent years.
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